What is Acomplia ?

A single pill has been found to stop both food and cigarette cravings enough to help people quit smoking and lose weight, and could also help curb other unhealthy urges. Named Acomplia the drug in one study helped people who were overweight drop an average of 20 pounds and in another doubled the chances that smokers would quit. Acomplia is made by French firm Sanofi-Synthelabo and the company says it could be available as early as 2006. Acomplia contains the active ingredient Rimonabant.

How Acomplia works?

Rimonabant (which will be brought to market as Acomplia) works by blocking the CB1 receptor, one of two receptors found in a newly described physiological system called the Endocannabinoid System (EC System), believed to play a critical role in the regulation of food intake and energy expenditure.

Researchers wondered whether a drug that halted this action might curb appetite, and in 2001, the first animal study was conducted at the National Institute of Alcohol Abuse and Alcoholism in Bethesda, Md.

In the study, genetically altered mice that lacked cannabinoid receptors ate less than their litter mates, even after 18 hours of fasting. When the normal mice were given rimonabant, which blocked their CB1 receptors, the mice reduced their food intake.In 2002, Sanofi-Synthelabo began human testing.

Acomplia works by selectively targeting and blocking the CB1 receptors, helping normalize the over-activation of the EC system and making hunger or cigarette cravings more manageable.

This blocking of signals that control cravings appears to result in weight loss, improvement of cardiovascular/ metabolic risk factors in overweight/obese patients and appears to reduce tobacco dependence without post cessation weight gain in people who smoke.

Side Effects?
Acomplia was said to be well tolerated in early tests. The only relatively common side effects were mild GI side effects and dizziness, and these were said to be transient.

Acomplia compared to other weight-loss drugs?

The side-effects of weight-loss-drugs already on the market are quite significant. Xenial for example can in many cases give severe diarrhea making it impossible for some patients to continue using the drug. Meridia (Reductil in Europe) was originally a drug meant to treat depressions and can have severe side-effects as well, like high blood pressure, sleeping problems (Insomnia), constipation and dry-mouth syndrome. Phentermine stimulates the central nervous system, making the body run on "full throttle" all the time. This causes a lot of strain on many of the body systems and phentermine should therefore not be used for longer periods and only in obesity cases and not for treating common overweight.

What is Phentermine?

Oral Phentermine Hydrochloride (HCL) is sold for weight loss. It is in the Sympathomimetic family of appetite suppressants (used for the short-term management of exogenous obesity.) When used in conjunction with diet, exercise, and behavior therapy, Phentermine may help you to lose weight while you are learning new ways to eat and to exercise.

How does Phentermine work?

Phentermine works by stimulating the hypothalamus gland and affecting certain neurotransmitters to decrease appetite. The hypothalamus is the region of the brain that controls the autonomic nervous system, regulating sleep cycles, body temperature, appetite, etc

Phentermine Dosing

Phentermine is meant to be used an appetite suppressant, to help you control how hungry feel. When using the capsule form to control your appetite, depending on your hunger needs, you can take either 30mg phentermine or 37.5 mg Phentermine in the morning before you would be eating breakfast. Starting out with the smaller dosage for a week, if you find that Phentermine is not controlling how hungry you feel you can increase to the 37.5 mg. Do not take more than the 37.5 mgs at any one time to control your hunger. The pills can be taken in the morning or in the afternoon when you find that you are hungriest during the day to help curb your appetite.

Your health is the most important thing to us. We will NOT put profits and sales ahead of your health. What this means is that if a phentermine prescription is not right for you, in the opinion of our doctors, you will NOT be allowed to order phentermine from Palm Valley Rx.com.

Acomplia looks very promising due to the few, or even non-existing, side-effects and due to the very promising effects it has on overweight, blood fat levels, blood sugar levels and subsequently to many of our most lethal cardio-vascular diseases.

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